α1-Adrenergic Receptor Subtypes in Nonfailing and Failing Human Myocardium
نویسندگان
چکیده
منابع مشابه
1-Adrenergic Receptor Subtypes in Nonfailing and Failing Human Myocardium
Background— 1-adrenergic receptors ( 1-ARs) play adaptive roles in the heart and protect against the development of heart failure. The 3 1-AR subtypes, 1A, 1B, and 1D, have distinct physiological roles in mouse heart, but very little is known about 1 subtypes in human heart. Here, we test the hypothesis that the 1A and 1B subtypes are present in human myocardium, similar to the mouse, and are n...
متن کامل{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.
BACKGROUND alpha1-adrenergic receptors (alpha1-ARs) play adaptive roles in the heart and protect against the development of heart failure. The 3 alpha1-AR subtypes, alpha1A, alpha1B, and alpha1D, have distinct physiological roles in mouse heart, but very little is known about alpha1 subtypes in human heart. Here, we test the hypothesis that the alpha1A and alpha1B subtypes are present in human ...
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BACKGROUND Recognizing that inhibitors of phosphodiesterase type 5 (PDE5) are increasingly employed in patients with pulmonary hypertension and right ventricular (RV) failure, we examined PDE5 expression in the human RV and its impact on myocardial contractility. METHODS AND RESULTS Tissue extracts from the RV of 20 patients were assayed for PDE5 expression using immunoblot and immunohistoche...
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BACKGROUND Receptors that couple via the stimulatory G protein, Gs, to adenylate cyclase and to a positive inotropic response have been extensively investigated in falling human heart. In contrast, much less is known about receptors, such as the A1-adenosine receptor, that couple to adenylate cyclase via the inhibitory G protein, Gi, to give a negative inotropic response. Activation of such Gi-...
متن کاملRate dependence of [Na+]i and contractility in nonfailing and failing human myocardium.
BACKGROUND In the failing human heart, altered Ca2+ homeostasis causes contractile dysfunction. Because Ca2+ and Na+ homeostasis are intimately linked through the Na+/Ca2+ exchanger, we compared the regulation of [Na+]i in nonfailing (NF) and failing human myocardium. METHODS AND RESULTS [Na+]i was measured in SBFI-loaded muscle strips. At slow pacing rates (0.25 Hz, 37 degrees C), isometric ...
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ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2009
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.108.846212